Priority 1
What to do first
1. Verify whether the lithium level was drawn as a trough, commonly about 12 hours after the last dose.
2. Compare the level with the ordered target and symptoms.
3. Assess hydration, sodium intake, renal function, and medication changes.
Safety
Hold If
Notify the provider and follow protocol if the lithium level is high, the patient has toxicity symptoms, or there is dehydration, severe vomiting/diarrhea, worsening renal function, or neurologic change.
Do not independently change lithium dosing or start electrolyte therapy.
Monitoring
Labs to Watch
Classic NCLEX memory rule: lithium 0.6-1.2 mEq/L for maintenance; toxicity concern around >=1.5 mEq/L.
Current clinical targets vary by phase of therapy, age, tolerability, and prescriber goal. Monitor renal function, sodium, thyroid function, and pregnancy status when applicable.